Helicobacter Pylori Infection, interleukin-1 Gene Polymorphisms and the Risk of Colorectal Cancer: Evidence From a Case-Control Study in Germany

Eur J Cancer. 2007 May;43(8):1283-9. doi: 10.1016/j.ejca.2007.03.005. Epub 2007 Apr 18.

Abstract

Helicobacter pylori infection is a strong risk factor for gastric cancer. A positive association with colorectal cancer has also been suggested, but available evidence remains inconclusive. In this population-based case-control study we investigated the association between H. pylori seroprevalence and colorectal adenocarcinoma under consideration of pro-inflammatory gene polymorphisms (384 incident cancer patients, 467 matched control subjects). Overall, the H. pylori seroprevalence was higher among cases (51%) than among controls (44%), and a positive association between H. pylori seroprevalence and colorectal adenocarcinoma risk was found, that persisted after adjustment for known potential confounders, including measures of socioeconomic status (odds ratio (OR)=1.41; 95% confidence intervals (CI), 1.06-1.87). Presence of specific H. pylori cytotoxin-associated gene A (CagA) antibodies did not significantly affect the observed risk. Additionally, a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection. H. pylori positive subjects carrying the pro-inflammatory genotypes even had a lower risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / etiology*
  • Adult
  • Aged
  • Case-Control Studies
  • Colorectal Neoplasms / etiology*
  • Female
  • Genotype
  • Helicobacter Infections / complications*
  • Helicobacter pylori*
  • Humans
  • Interleukin-1 / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Genetic / genetics*
  • Risk Factors

Substances

  • Interleukin-1