The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations

Am J Respir Crit Care Med. 2007 Jul 15;176(2):167-73. doi: 10.1164/rccm.200611-1723OC. Epub 2007 Apr 19.


Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disease influenced by multiple genes and environmental factors. A region on chromosome 2q has been shown to be linked to COPD. A positional candidate gene from the chromosome 2q region SERPINE2 (Serpin peptidase inhibitor, clade E [nexin, plasminogen activator inhibitor type 1], member 2), was previously evaluated as a susceptibility gene for COPD in two association studies, but the results were contradictory.

Objectives: To identify the relationship between SERPINE2 polymorphisms and COPD-related phenotypes using family-based and case-control association studies.

Methods: In the present study, we genotyped 25 single nucleotide polymorphisms (SNPs) from SERPINE2 and analyzed qualitative and quantitative COPD phenotypes in 635 pedigrees with 1,910 individuals and an independent case-control population that included 973 COPD cases and 956 control subjects. The family data were analyzed using family-based association tests. The case-control data were analyzed using logistic regression and linear models.

Measurements and main results: Six SNPs demonstrated significant associations with COPD phenotypes in the family-based association analysis (0.0016<or=p<or=0.042). Five of these SNPs demonstrated replicated associations in the case-control analysis (0.021<or=p<or=0.031). In addition, the results of haplotype analyses supported the results from single SNP analyses.

Conclusions: These data provide further support for SERPINE2 as a COPD susceptibility gene.

MeSH terms

  • Aged
  • Amyloid beta-Protein Precursor / genetics*
  • Case-Control Studies
  • Databases, Genetic
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Phenotype
  • Polymorphism, Single Nucleotide / genetics*
  • Protease Nexins
  • Pulmonary Disease, Chronic Obstructive / genetics*
  • Receptors, Cell Surface / genetics*
  • Serpin E2


  • Amyloid beta-Protein Precursor
  • Protease Nexins
  • Receptors, Cell Surface
  • SERPINE2 protein, human
  • Serpin E2