Atypical neurothekeoma: a new case and review of the literature

J Cutan Pathol. 2007 May;34(5):435-7. doi: 10.1111/j.1600-0560.2006.00637.x.


Background: Neurothekeoma is a rare neoplasm ascribed into the broad category of benign peripheral nerve sheath tumors. The atypical cellular variant of this neoplasm, showing a peculiar histological pattern, has been very rarely reported in literature.

Methods: The clinical, histopathological and immunohistochemical profile of a new case of atypical cellular neurothekeoma in a 32-year-old woman is reported.

Results: The described neoplasm showed the histological features of atypical variant of cellular neurothekeoma with high-rate mitotic activity and deep penetration into subcutaneous fat.

Conclusions: Because only few cases of atypical neurothekeoma have been reported in literature, clinical and morphological available data on this neoplasm are very few, and its prognosis remains uncertain; anyway, dermatologists should be aware of histological features of this neoplasm for which a complete surgical excision is recommended.

MeSH terms

  • Adult
  • Chin / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Neurothekeoma / metabolism
  • Neurothekeoma / pathology*
  • Soft Tissue Neoplasms / metabolism
  • Soft Tissue Neoplasms / pathology*