Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2007 Aug;57(2):247-56.
doi: 10.1016/j.jaad.2007.01.046. Epub 2007 Apr 19.

The Effect of a High-Protein, Low Glycemic-Load Diet Versus a Conventional, High Glycemic-Load Diet on Biochemical Parameters Associated With Acne Vulgaris: A Randomized, Investigator-Masked, Controlled Trial

Affiliations
Randomized Controlled Trial

The Effect of a High-Protein, Low Glycemic-Load Diet Versus a Conventional, High Glycemic-Load Diet on Biochemical Parameters Associated With Acne Vulgaris: A Randomized, Investigator-Masked, Controlled Trial

Robyn N Smith et al. J Am Acad Dermatol. .

Abstract

Background: No previous study has sought to examine the influence of dietary composition on acne vulgaris.

Objective: We sought to compare the effect of an experimental low glycemic-load diet with a conventional high glycemic-load diet on clinical and endocrine aspects of acne vulgaris.

Methods: A total of 43 male patients with acne completed a 12-week, parallel, dietary intervention study with investigator-masked dermatology assessments. Primary outcomes measures were changes in lesion counts, sex hormone binding globulin, free androgen index, insulin-like growth factor-I, and insulin-like growth factor binding proteins.

Results: At 12 weeks, total lesion counts had decreased more in the experimental group (-21.9 [95% confidence interval, -26.8 to -19.0]) compared with the control group (-13.8 [-19.1 to -8.5], P = .01). The experimental diet also reduced weight (P = .001), reduced the free androgen index (P = .04), and increased insulin-like growth factor binding protein-1 (P = .001) when compared with a high glycemic-load diet.

Limitations: We could not preclude the role of weight loss in the overall treatment effect.

Conclusion: This suggests nutrition-related lifestyle factors play a role in acne pathogenesis. However, these preliminary findings should be confirmed by similar studies.

Comment in

  • Dietary fat, fiber, and acne vulgaris.
    Logan AC. Logan AC. J Am Acad Dermatol. 2007 Dec;57(6):1092-3. doi: 10.1016/j.jaad.2007.06.046. J Am Acad Dermatol. 2007. PMID: 18021854 No abstract available.

Similar articles

See all similar articles

Cited by 35 articles

See all "Cited by" articles

Publication types

Feedback