miR-1-2 gets to the heart of the matter

Cell. 2007 Apr 20;129(2):247-9. doi: 10.1016/j.cell.2007.04.008.


Although many microRNAs (miRNAs) and their targets have been identified, the importance of miRNAs in vivo is still unclear. In this issue, Zhao et al. (2007) generate mice deficient in a cardiac-specific miRNA, miR-1-2, and reveal that this microRNA plays a crucial role in heart development and physiology.

Publication types

  • Comment

MeSH terms

  • Animals
  • Heart / embryology*
  • Heart / physiology*
  • Mice
  • MicroRNAs / genetics
  • MicroRNAs / physiology*


  • MicroRNAs