Impaired arginine-vasopressin-induced aldosterone release from adrenal gland cells in mice lacking the vasopressin V1A receptor

Eur J Pharmacol. 2007 Jul 2;566(1-3):226-30. doi: 10.1016/j.ejphar.2007.03.022. Epub 2007 Mar 24.

Abstract

We examined aldosterone release in response to stimulation with arginine-vasopressin (AVP) using adrenal gland cells. AVP caused a significant increase in aldosterone release from the dispersed adrenal gland cells of wild-type mice (V1AR+/+) at concentrations from 0.1 microM to 1 microM. In contrast, AVP-induced aldosterone release was impaired in adrenal gland cells from mice lacking the vasopressin V1A receptor (V1AR-/-), while adrenocorticotropic hormone (ACTH)-induced aldosterone release in V1AR-/- mice was not significantly different from that in V1AR+/+ mice. In addition, a vasopressin V1A receptor-selective antagonist 1-[1-[4-(3-acetylaminopropoxy)benzoyl]-4-piperidyl]-3,4-dihydro-2(1H)-quinolinone (OPC-21268) potently inhibited AVP-induced aldosterone release. Thus, our study clearly demonstrates that AVP-induced aldosterone release from adrenal gland cells is mediated via the vasopressin V1A receptor in mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Glands / cytology
  • Adrenal Glands / metabolism*
  • Adrenocorticotropic Hormone / blood
  • Adrenocorticotropic Hormone / pharmacokinetics
  • Adrenocorticotropic Hormone / pharmacology
  • Aldosterone / blood*
  • Animals
  • Arginine Vasopressin / pharmacology*
  • Cells, Cultured
  • Male
  • Mice
  • Mice, Knockout
  • RNA, Messenger / metabolism
  • Receptors, Vasopressin / genetics
  • Receptors, Vasopressin / metabolism*

Substances

  • RNA, Messenger
  • Receptors, Vasopressin
  • Arginine Vasopressin
  • Aldosterone
  • Adrenocorticotropic Hormone