Further studies on the antinociceptive activity and respiratory effects of buprenorphine in sheep

J Vet Pharmacol Ther. 1991 Sep;14(3):230-4. doi: 10.1111/j.1365-2885.1991.tb00831.x.

Abstract

The thermal and mechanical analgesic profile of buprenorphine at a dose rate of 1.5 micrograms/kg i.v. was investigated in five sheep. This dose produced significant analgesia for 40 min against the thermal stimulus, but no mechanical antinociception. A higher dose rate of 12 micrograms/kg also failed to produce antinociception to a mechanical stimulus. In addition, the effect of the drug (6 micrograms/kg) on respiratory gas tensions was determined and no significant changes were observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesia / veterinary*
  • Animals
  • Bicarbonates / blood
  • Blood Gas Analysis
  • Buprenorphine / administration & dosage
  • Buprenorphine / pharmacology*
  • Carbon Dioxide / blood
  • Dose-Response Relationship, Drug
  • Female
  • Hot Temperature
  • Hydrogen-Ion Concentration
  • Injections, Intravenous / veterinary
  • Nociceptors / drug effects*
  • Oxygen / blood
  • Respiration / drug effects*
  • Sensory Thresholds
  • Sheep / physiology*

Substances

  • Bicarbonates
  • Carbon Dioxide
  • Buprenorphine
  • Oxygen