Resveratrol inhibition of Propionibacterium acnes

J Antimicrob Chemother. 2007 Jun;59(6):1182-4. doi: 10.1093/jac/dkm099. Epub 2007 Apr 21.


Objectives: To evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on Propionibacterium acnes growth.

Methods: Three different strains of P. acnes were tested against resveratrol at concentrations between 0 and 200 mg/L. Piceatannol was included as a second hydroxystilbene to compare with resveratrol, and erythromycin and benzoyl peroxide were used as positive controls.

Results: After 24 h of treatment with resveratrol, the average 50% inhibitory concentration (IC(50)) was 73 mg/L and the average 100% inhibitory concentration (IC(100)) was 187 mg/L for the three strains of P. acnes tested. The IC(50) and IC(100) of piceatannol were 123 and 234 mg/L, respectively. The highest concentration of resveratrol tested (200 mg/L) was bactericidal, whereas lower concentrations were bacteriostatic.

Conclusions: Resveratrol, an anti-inflammatory hydroxystilbene, is capable of inhibiting P. acnes growth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Benzoyl Peroxide / pharmacology
  • Dose-Response Relationship, Drug
  • Erythromycin / pharmacology
  • Keratolytic Agents / pharmacology
  • Microbial Sensitivity Tests
  • Propionibacterium acnes / drug effects*
  • Propionibacterium acnes / growth & development
  • Resveratrol
  • Stilbenes / pharmacology*


  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Keratolytic Agents
  • Stilbenes
  • Erythromycin
  • 3,3',4,5'-tetrahydroxystilbene
  • Resveratrol
  • Benzoyl Peroxide