Stem-cell niches: nursery rhymes across kingdoms

Nat Rev Mol Cell Biol. 2007 May;8(5):345-54. doi: 10.1038/nrm2164.


Despite the large evolutionary distance between the plant and animal kingdoms, stem cells in both reside in specialized cellular contexts called stem-cell niches. Although stem-cell-specification factors have been recruited from plant-specific gene families, maintenance factors that repress stem-cell differentiation are conserved between plants and animals. Recent evidence indicates that stem cells in multicellular organisms can be specified by kingdom-specific patterning mechanisms that connect to a related core of epigenetic stem-cell factors.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Body Patterning / physiology
  • Chromatin Assembly and Disassembly / physiology
  • Epigenesis, Genetic
  • Models, Biological
  • Plant Cells*
  • Plant Roots / cytology
  • Plant Shoots / cytology
  • Seeds
  • Stem Cells / cytology*