Concomitant presentation of acute myeloid leukemia with T-cell large granular lymphocytic leukemia

Acta Oncol. 2007;46(2):247-9. doi: 10.1080/02841860600827139.


T-cell large granular lymphocyte leukemia (T-LGL) also known as T-cell chronic lymphocytic leukemia is rare and comprises a small minority of all small lymphocytic leukemias. The concomitant presentation of T-LGL with acute myeloid leukemia (AML) has not been previously reported. We present an elderly gentleman with concomitant T-LGL and AML (non-M3) diagnosed by a combination of morphologic evaluation, immunophenotyping by flow cytometry, and T-cell gene rearrangement studies. The patient was managed with combination AML chemotherapy. He remains alive and well seven months after initial diagnosis. A brief review of literature is also presented.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Aged, 80 and over
  • Antigens, CD / analysis
  • Flow Cytometry
  • Humans
  • Leukemia, Myeloid / complications
  • Leukemia, Myeloid / diagnosis*
  • Leukemia, Prolymphocytic, T-Cell / diagnosis*
  • Male


  • Antigens, CD