Detection of early vessel leakiness in acute ischemic stroke using computed tomography perfusion may indicate hemorrhagic transformation

Acta Radiol. 2007 Apr;48(3):341-4. doi: 10.1080/02841850601182170.


This short communication presents significantly increased permeability in two patients with acute stroke, indicating an early blood-brain barrier disruption. Neither of the patients had undergone any thrombolytic therapy and hemorrhaged later. Increased permeability was assessed in both patients using a distributed-parameter model of capillary-tissue exchange. Our findings indicate that early physiologic imaging in stroke may identify patients with a high risk of hemorrhagic transformation by revealing pathologic vascular changes and, thus, guide therapeutic options.

Publication types

  • Case Reports

MeSH terms

  • Cerebral Hemorrhage / diagnostic imaging*
  • Cerebrovascular Circulation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Stroke / diagnostic imaging*
  • Tomography, X-Ray Computed*