Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 129 (2), 318-20

Elevated Circulating Tumor Necrosis Factor Levels in Alzheimer's Disease

Affiliations

Elevated Circulating Tumor Necrosis Factor Levels in Alzheimer's Disease

H Fillit et al. Neurosci Lett.

Abstract

Recent investigations have demonstrated a local inflammatory response in Alzheimer's disease (AD), including microglia and cytokines. Levels of the cytokine tumor necrosis factor alpha (TNF-alpha) in sera from patients with AD and age-matched controls were measured by an enzyme-linked immunoassay and a cytotoxicity bioassay. Significantly elevated levels of TNF were found in AD sera compared to controls. Elevated circulating TNF may be derived from the local CNS inflammatory reaction in AD, and may account for some systemic manifestations of AD such as weight loss. Future studies may determine if, in the absence of complicating disorders which may elevate TNF, circulating TNF could be a marker of AD inflammatory activity.

Similar articles

See all similar articles

Cited by 115 PubMed Central articles

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources

Feedback