A hypocaloric diet enriched in legumes specifically mitigates lipid peroxidation in obese subjects

Free Radic Res. 2007 Apr;41(4):498-506. doi: 10.1080/10715760601131935.


Legume intake could specifically protect against lipid peroxidation in addition to the effects associated to weight loss when included in hypocaloric diets. Thus, 30 obese subjects (age: 36 +/- 8 years and BMI: 32.0 +/- 5.3 kg/m(2)) were nutritionally treated by a 8-week energy restriction ( - 30% energy expenditure) with a legume enriched diet (4 days/week servings, [image omitted] ) or without legumes (control diet (CD), [image omitted] ). Body weight, circulating cholesterol, oxidized LDL (ox-LDL), malondialdehyde (MDA) and urinary 8-isoprostane F(2alpha) (8-iso-PGF(2alpha)) were measured at baseline and at endpoint. After the nutritional intervention, all obese subjects lost weight, specially those individuals who followed the legumes-enriched diet as compared to the CD ( - 7.7 +/- 3 vs. - 5.3 +/- 2.7%; p = 0.023), which was accompanied by marked decreases in total cholesterol levels (p < 0.001) and statistically significant diet-related reductions on plasma ox-LDL, plasma MDA and urinary 8-iso-PGF(2alpha) output. Therefore, a balanced diet with moderate caloric restriction including 4 day/week legume servings empowered the oxidative stress improvement related to weight loss through a reduction in lipid peroxidation as compared to a control hypocaloric diet.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antioxidants / chemistry
  • Body Mass Index
  • Body Weight
  • Caloric Restriction*
  • Cholesterol / metabolism
  • F2-Isoprostanes / metabolism
  • Fabaceae / metabolism*
  • Female
  • Humans
  • Lipid Peroxidation
  • Male
  • Middle Aged
  • Obesity / pathology*
  • Oxidative Stress


  • Antioxidants
  • F2-Isoprostanes
  • Cholesterol