Infective endocarditis due to community-associated methicillin-resistant Staphylococcus aureus in injection drug users may be associated with Panton-Valentine leukocidin-negative strains

Scand J Infect Dis. 2007;39(4):299-302. doi: 10.1080/00365540601003803.


Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates that cause infective endocarditis in injection drug users (IDUs) are distinct from CA-MRSA strains that cause endocardial infection as a complication of skin and soft tissue infections. We present a case of CA-MRSA infective endocarditis, review pertinent cases previously published, and describe the molecular characteristics of strains from IDUs and patients with skin and soft tissue infections.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Community-Acquired Infections / microbiology
  • Endocarditis, Bacterial / drug therapy
  • Endocarditis, Bacterial / microbiology*
  • Endocarditis, Bacterial / surgery
  • Humans
  • Male
  • Methicillin Resistance*
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / microbiology*
  • Staphylococcal Infections / surgery
  • Staphylococcus aureus / classification
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / pathogenicity*
  • Substance Abuse, Intravenous / microbiology*
  • Tricuspid Valve / microbiology