Progressive early dermatologic changes in Hutchinson-Gilford progeria syndrome

Pediatr Dermatol. 1991 Sep;8(3):199-206. doi: 10.1111/j.1525-1470.1991.tb00859.x.

Abstract

We describe evolving dermatologic findings in a male with progeria from age 1 month to 21.5 months. At 18 months of age, irregular pigmentary changes of the abdomen, early occipital alopecia, superficial scalp veins, glyphic nasal tip, absent ear lobules, coarse hair that stands on end, crowded dentition with delayed tooth development, and dystrophic nails permitted the diagnosis of progeria. Radiographs showed evidence of resorption of the distal ends of the clavicles, attenuation of the terminal phalanges, diffuse osteopenia, and fishmouth vertebral bodies, which are typical of this syndrome. Appreciation of the evolution of early dermatologic findings may permit earlier diagnosis of this condition in infants with skin changes.

Publication types

  • Case Reports

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Infant
  • Male
  • Progeria / complications
  • Progeria / diagnosis*
  • Skin Diseases / diagnosis*
  • Skin Diseases / etiology
  • Time Factors