Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphisms do not affect early functional and structural changes in atherosclerosis: the Cardiovascular Risk in Young Finns study

Circ J. 2007 May;71(5):741-5. doi: 10.1253/circj.71.741.


Background: The present study was designed to investigate the effects of apoB XbaI and apoA-I/C-III/A-IV SstI polymorphisms to carotid artery intima-media thickness (IMT), carotid artery compliance (CAC) and brachial artery flow-mediated vasodilatation (FMD).

Methods and results: As part of the Cardiovascular Risk in Young Finns Study, the carotid IMT, CAC and brachial FMD of 2,265 subjects (mean age +/- SD 32 +/-5 years) were measured with ultrasonography, and genotyping of the apolipoprotein polymorphisms was performed. The frequencies of the genotypes did not differ between the groups with high (above median 0.57 mm) and low (below median) IMT, CAC or FMD. The average carotid IMT differed between the 3 apoB XbaI genotypes (ANOVA, p=0.04), but not between the apoA-I/C-III/A-IV SstI genotypes (ANOVA, p=0.53). The relationship between the polymorphisms and carotid IMT was not significant in any of the covariate-adjusted logistic and linear regression analyses. CAC and FMD were not influenced by either of the polymorphisms in ANOVA and regression analyses.

Conclusions: The polymorphisms apoA-I/C-III/A-IV SstI and apoB XbaI do not seem to affect carotid artery characteristics or brachial artery FMD in young adulthood.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Analysis of Variance
  • Apolipoprotein A-I / genetics
  • Apolipoprotein C-III / genetics
  • Apolipoproteins / genetics*
  • Apolipoproteins A / genetics
  • Apolipoproteins B / genetics
  • Atherosclerosis / diagnostic imaging*
  • Atherosclerosis / genetics
  • Atherosclerosis / physiopathology*
  • Brachial Artery / diagnostic imaging
  • Brachial Artery / physiopathology
  • Carotid Arteries / diagnostic imaging
  • Carotid Arteries / physiopathology
  • Child
  • Child, Preschool
  • Compliance
  • Female
  • Humans
  • Linear Models
  • Logistic Models
  • Male
  • Polymorphism, Genetic*
  • Regional Blood Flow
  • Tunica Intima / diagnostic imaging
  • Tunica Media / diagnostic imaging
  • Ultrasonography
  • Vasodilation


  • Apolipoprotein A-I
  • Apolipoprotein C-III
  • Apolipoproteins
  • Apolipoproteins A
  • Apolipoproteins B
  • apolipoprotein A-IV