Immune evasion by Kaposi's sarcoma-associated herpesvirus

Nat Rev Immunol. 2007 May;7(5):391-401. doi: 10.1038/nri2076.

Abstract

To efficiently establish a persistent infection, Kaposi's sarcoma-associated herpesvirus (KSHV; also known as HHV8) dedicates a large amount of its coding potential to produce proteins that antagonize the immune system of its host. These viral immunomodulators interfere with both the innate and adaptive immune responses and most of them are homologous to cellular proteins, suggesting that they have been pirated from the host during viral evolution. In this Review, I present recent advances in the understanding of immune evasion by KSHV, with a particular focus on the virally encoded modulators of immune responses that are unique to this virus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA, Viral / genetics
  • DNA, Viral / immunology
  • Herpesvirus 8, Human / genetics
  • Herpesvirus 8, Human / immunology*
  • Humans
  • Models, Immunological*
  • Sarcoma, Kaposi / immunology
  • Sarcoma, Kaposi / virology
  • Viral Proteins / genetics
  • Viral Proteins / immunology*

Substances

  • DNA, Viral
  • Viral Proteins