CCR5 and CCR3 expression on T CD3+ lymphocytes from HIV/Leishmania co-infected subjects

Med Microbiol Immunol. 2007 Dec;196(4):253-5. doi: 10.1007/s00430-007-0046-1. Epub 2007 Apr 25.


CC chemokine receptor 5 (CCR5) and CC chemokine receptor 3 (CCR3) are membrane-bound proteins involved in HIV-1 entry into susceptible cells. All T lymphocyte subsets display CCR5 and CCR3 on their membrane surface. T helper 1 cells are known to express CCR5 but not CCR3, and most of T cells expressing CCR3 are T helper 2. This study aimed to assess the expression of CCR5 and CCR3 on peripheral blood CD3+ T lymphocytes of HIV-Leishmania co-infected individuals. A total of 36 subjects were enrolled; nine had HIV-Leishmania co-infection; nine were HIV-infected without Leishmania, nine had visceral leishmaniasis without HIV co-infection and nine were healthy blood donors. HIV-Leishmania co-infected subjects showed a significantly higher rate of CCR5+CD3+ T lymphocytes in comparison with the other studied groups. The higher rate of CD3+ T-cells expressing CCR5 found in HIV-Leishmania co-infected subjects may be related to the role of Leishmania as an enhancer of the progression to AIDS.

MeSH terms

  • CD3 Complex / analysis*
  • HIV Infections / complications
  • HIV Infections / immunology*
  • Humans
  • Leishmaniasis / complications
  • Leishmaniasis / immunology*
  • Receptors, CCR3 / analysis*
  • Receptors, CCR5 / analysis*
  • T-Lymphocytes / immunology*


  • CCR3 protein, human
  • CD3 Complex
  • Receptors, CCR3
  • Receptors, CCR5