STAT3: a critical transcription activator in angiogenesis

Med Res Rev. 2008 Mar;28(2):185-200. doi: 10.1002/med.20101.


Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is a complex multistage process regulated by a number of signal transduction pathways. Accumulating evidence suggests that signal transducer and activator of transcription (STATs), mainly STAT3, play an important role in angiogenesis under both physiological and pathological conditions in addition to cell survival, proliferation, differentiation, and oncogenesis. STAT3, as a critical multifunctional mediator, regulates many aspects of angiogenesis at the transcriptional level. This review will highlight the pivotal role of STAT3 in well-studied tumorous angiogenesis and cardiac angiogenesis, and summarize various potential mechanisms utilized by STAT3 to regulate the transcriptional activation of VEGF.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Coronary Vessels / growth & development
  • Humans
  • Neoplasms / blood supply
  • Neovascularization, Pathologic / physiopathology*
  • Neovascularization, Physiologic / physiology*
  • STAT3 Transcription Factor / physiology*
  • Signal Transduction
  • Transcriptional Activation / physiology
  • Vascular Endothelial Growth Factor A / biosynthesis
  • Vascular Endothelial Growth Factor A / physiology


  • STAT3 Transcription Factor
  • Vascular Endothelial Growth Factor A