Hypoxia, gene expression, and metastasis

Cancer Metastasis Rev. 2007 Jun;26(2):333-9. doi: 10.1007/s10555-007-9063-1.


Hypoxia poses many problems to the treatment of cancer. Hypoxic tumors are more resistant to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible for increased invasion, aggressiveness, and metastasis of tumors. The augmented metastatic potential due to hypoxia-mediated gene expression is discussed in this section. Particular attention is given to recent studies of specific genes involved in the key steps of metastasis, including extracellular matrix interactions, migration, and proliferation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Division
  • Cell Hypoxia / genetics
  • Cell Hypoxia / physiology*
  • Cell Movement
  • Cell Survival
  • Connective Tissue Growth Factor
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Immediate-Early Proteins / physiology
  • Intercellular Signaling Peptides and Proteins / physiology
  • Neoplasm Invasiveness
  • Neoplasm Metastasis / genetics*
  • Neoplasms / radiotherapy
  • Neovascularization, Pathologic


  • CCN2 protein, human
  • Immediate-Early Proteins
  • Intercellular Signaling Peptides and Proteins
  • Connective Tissue Growth Factor