A randomized study of the effects of preoperative ketorolac on general anaesthesia for caesarean section

Int J Obstet Anesth. 2007 Jul;16(3):214-20. doi: 10.1016/j.ijoa.2007.01.012. Epub 2007 Apr 24.

Abstract

Background: Ketorolac may attenuate the maternal stress response to tracheal intubation, while avoiding opioid-induced neonatal depression. We aimed to evaluate the haemodynamic and hormonal effects of prophylactic ketorolac on surgical stress and analgesia after caesarean delivery.

Methods: After ethical approval, 90 patients scheduled for elective caesarean delivery were randomly allocated receive either ketorolac 15 mg i.v. bolus 20 min before induction, followed by an infusion of 7.5 mg/h (n=45), or saline placebo (n=45). Anaesthesia was maintained with 50% nitrous oxide in oxygen with 0.5% isoflurane. Haemodynamic variables, plasma cortisol concentrations, uterine relaxation, need for supplementary doses of oxytocin, peri-operative blood loss, haematocrit, Apgar scores at 1 and 5 min, postoperative pain scores at rest and movement, and tramadol consumption were recorded.

Results: After induction, patients receiving ketorolac had a smaller increase in heart rate, systolic and mean arterial blood pressure (P<0.001) and lower plasma cortisol concentrations, (32.2+/-7.61 vs. 45+/-15.1 microg/dL, P<0.05), lower pain scores at rest and movement for the first two postoperative hours (P<0.001) and a longer time to first request for analgesia. Fewer patients in the ketorolac group received tramadol in the four hours after surgery (7 (15.6%) vs. 14 (31.1%), P=0.004). There were no differences between groups in peri-operative blood loss, vomiting or Apgar scores. There was no echocardiographic evidence of premature closure of the ductus arteriosus in the newborns.

Conclusion: Prophylactic ketorolac is safe and effective in attenuating the maternal stress response to intubation and improves the quality of analgesia after caesarean delivery.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anesthesia, General*
  • Anesthesia, Obstetrical*
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Apgar Score
  • Blood Pressure / physiology
  • Cesarean Section*
  • Double-Blind Method
  • Female
  • Heart Rate / physiology
  • Histamine H2 Antagonists / therapeutic use
  • Humans
  • Hydrocortisone / blood
  • Infant, Newborn
  • Ketorolac / adverse effects
  • Ketorolac / therapeutic use*
  • Monitoring, Intraoperative
  • Pain Measurement
  • Pain, Postoperative / drug therapy
  • Pregnancy
  • Preoperative Care*
  • Ranitidine / therapeutic use
  • Stress, Psychological / blood
  • Stress, Psychological / physiopathology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Histamine H2 Antagonists
  • Ranitidine
  • Hydrocortisone
  • Ketorolac