Neuroregulator RET initiates Peyer's-patch tissue genesis

Satoshi Fukuyama; Hiroshi Kiyono

doi:10.1016/j.immuni.2007.04.004

Neuroregulator RET initiates Peyer's-patch tissue genesis

Immunity. 2007 Apr;26(4):393-5. doi: 10.1016/j.immuni.2007.04.004.

Authors

Satoshi Fukuyama¹, Hiroshi Kiyono

Affiliation

¹ Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

PMID: 17459808
DOI: 10.1016/j.immuni.2007.04.004

Abstract

The tyrosine kinase receptor RET regulates the intestinal nervous system. A recent paper by Veiga-Fernandes et al. (2007) demonstrates that RET is also involved in the intestinal immune system through the initiation of Peyer's-patch tissue genesis.

Publication types

Comment

MeSH terms

Animals
Intestines / immunology*
Intestines / innervation
Male
Peyer's Patches / growth & development*
Proto-Oncogene Proteins c-ret / genetics
Proto-Oncogene Proteins c-ret / physiology*

Substances

Proto-Oncogene Proteins c-ret
Ret protein, mouse