Serum level of interferon-gamma in autoimmune diseases

Tohoku J Exp Med. 1991 Aug;164(4):259-67. doi: 10.1620/tjem.164.259.


Interferon-gamma is one of the cytokines which have various immunoregulatory functions. In the present study, the serum interferon-gamma level was determined in autoimmune diseases. It was increased in the active cases of systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). Since there was a positive correlation between the serum interferon-gamma level and the rate of peripheral mononuclear cells positive for HLA-DR antigen in systemic lupus erythematosus, circulating interferon-gamma might have a biological functions as suggested by many in vitro studies. In rheumatoid arthritis and Sjögren's syndrome, there was no correlation between the serum interferon-gamma level and the clinical findings. These data suggest that interferon-gamma might be associated with the pathogenesis of autoimmune diseases such as SLE and MCTD, and it can be one of the indices for their disease activity.

MeSH terms

  • Antibodies, Anti-Idiotypic / analysis
  • Antibodies, Monoclonal
  • Antigens, Surface / analysis
  • Arthritis, Rheumatoid / blood
  • Arthritis, Rheumatoid / immunology
  • Autoimmune Diseases / blood*
  • Autoimmune Diseases / immunology
  • Biomarkers / blood
  • Complement System Proteins / analysis
  • Connective Tissue Diseases / blood
  • Connective Tissue Diseases / immunology
  • DNA / immunology
  • Humans
  • Interferon-gamma / blood*
  • Lupus Erythematosus, Systemic / blood
  • Lupus Erythematosus, Systemic / immunology
  • Monocytes / immunology
  • Prednisolone / therapeutic use
  • Reference Values
  • Sjogren's Syndrome / blood
  • Sjogren's Syndrome / immunology


  • Antibodies, Anti-Idiotypic
  • Antibodies, Monoclonal
  • Antigens, Surface
  • Biomarkers
  • Interferon-gamma
  • Complement System Proteins
  • DNA
  • Prednisolone