Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study

World J Gastroenterol. 2007 Mar 14;13(10):1585-94. doi: 10.3748/wjg.v13.i10.1585.

Abstract

Aim: To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.

Methods: This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients, 227 oesophageal adenocarcinoma patients and 260 controls. All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.

Results: Gastro-oesophageal reflux was associated with Barrett's [OR 12.0 (95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48 (95% CI 2.25-5.41)]. Oesophageal adenocarcinoma patients were more likely than controls to be ex- or current smokers [OR 1.72 (95% CI 1.06-2.81) and OR 4.84 (95% CI 2.72-8.61) respectively] and to have a high body mass index [OR 2.69 (95% CI 1.62-4.46)]. No significant associations were observed between these risk factors and Barrett's oesophagus. Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50 (95% CI 0.30-0.86)].

Conclusion: A high body mass index, a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / epidemiology*
  • Aged
  • Barrett Esophagus / epidemiology*
  • Body Mass Index
  • Case-Control Studies
  • Diet
  • Disease Progression
  • Esophageal Neoplasms / epidemiology*
  • Female
  • Fruit
  • Gastroesophageal Reflux / complications
  • Gastroesophageal Reflux / etiology
  • Humans
  • Male
  • Middle Aged
  • Northern Ireland
  • Risk Factors
  • Smoking / adverse effects