Treatment of acquired hemophilia A

J Thromb Haemost. 2007 May;5(5):893-900. doi: 10.1111/j.1538-7836.2007.02433.x.


Acquired hemophilia A (AH) is an autoimmune disease that leads to potentially severe bleeding. Management relies on rapid and accurate diagnosis, control of bleeding episodes and eradication of the inhibitor by immunosuppression. There is extensive literature about the disease but only few controlled data are available. This paper reviews the current literature on treatment strategies for hemostatic therapy and inhibitor eradication. Potential future developments are discussed.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Murine-Derived
  • Blood Coagulation Factors / therapeutic use
  • Child
  • Female
  • Hemophilia A / drug therapy*
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Immunosuppressive Agents / therapeutic use
  • Pregnancy
  • Pregnancy Complications, Hematologic / therapy
  • Rituximab


  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Blood Coagulation Factors
  • Immunoglobulins, Intravenous
  • Immunosuppressive Agents
  • Rituximab