HPV-related vulvar intraepithelial neoplasia: outcome of different management modalities

Int J Gynaecol Obstet. 2007 Oct;99(1):23-7. doi: 10.1016/j.ijgo.2007.03.023. Epub 2007 Apr 26.


Objective: To evaluate the outcome of various management schemes for HPV-related vulvar intraepithelial neoplasia (VIN, usual type).

Methods: Retrospective chart review of patients with histologically diagnosed grade 2/3-VIN who had at least one year of follow-up. The variables that were collected included patient characteristics, management modalities, and clinical outcome.

Results: Fifty patients with a median age of 45 years old were evaluated. The median duration of follow-up was 43.5 months (12-186). Complete response (CR) and partial response occurred in 28 (56%) and 4 (8%), respectively. Nineteen of 28 patients with CR recurred with VIN. Surgical excision yielded higher CR (77%) than did either ablational techniques (21-33%) or topical immunotherapy (33%).

Conclusion: In this experience, surgical excision for VIN, usual type, resulted in better therapeutic success rates than other treatment modalities. Management schemes should be individualized based on extent of disease and patient compliance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / therapeutic use
  • Adult
  • Aged
  • Aminoquinolines / therapeutic use
  • Carcinoma in Situ / therapy*
  • Carcinoma in Situ / virology
  • Catheter Ablation / methods
  • Female
  • Follow-Up Studies
  • Humans
  • Imiquimod
  • Laser Therapy / methods
  • Middle Aged
  • Papillomavirus Infections / complications*
  • Precancerous Conditions / therapy*
  • Precancerous Conditions / virology
  • Retrospective Studies
  • Treatment Outcome
  • Vulvar Neoplasms / therapy*
  • Vulvar Neoplasms / virology


  • Adjuvants, Immunologic
  • Aminoquinolines
  • Imiquimod