The many faces of the origin recognition complex

Curr Opin Cell Biol. 2007 Jun;19(3):337-43. doi: 10.1016/ Epub 2007 Apr 26.


The hetero-hexameric origin recognition complex (ORC) is well known for its separable roles in DNA replication and heterochromatin assembly. However, ORC and its individual subunits have been implicated in diverse cellular activities in both the nucleus and the cytoplasm. Some of ORC's implied functions, such as cell cycle checkpoint control and mitotic chromosome assembly, may be indirectly related to its roles in replication control and/or heterochromatin assembly. Other suggested roles in ribosomal biogenesis and in centrosome and kinetochore function are based on localization/interaction data and are as yet inconclusive. However, recent findings directly link ORC to sister chromatin cohesion, cytokinesis and neural dendritic branching.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Chromatin / chemistry
  • Chromatin / metabolism
  • Chromosomes / physiology
  • Cytokinesis / physiology
  • DNA Replication / physiology
  • Heterochromatin / genetics
  • Heterochromatin / metabolism
  • Humans
  • Kinetochores / physiology
  • Mitosis / physiology
  • Models, Biological
  • Origin Recognition Complex / genetics*
  • Origin Recognition Complex / metabolism*
  • Origin Recognition Complex / physiology


  • Cell Cycle Proteins
  • Chromatin
  • Heterochromatin
  • Origin Recognition Complex