p53 and NF-kappaB crosstalk: IKKalpha tips the balance

Mol Cell. 2007 Apr 27;26(2):158-9. doi: 10.1016/j.molcel.2007.04.006.

Abstract

Crosstalk between the NF-kappaB and p53 transcription factors can play a pivotal role in determining the cellular response to stress; in a recent issue of Molecular Cell, Huang et al. (2007) show that IkappaB kinase alpha (IKKalpha) can determine which pathway is dominant.

Publication types

  • Review
  • Comment

MeSH terms

  • Apoptosis
  • CREB-Binding Protein / metabolism
  • Humans
  • I-kappa B Kinase / metabolism*
  • NF-kappa B / metabolism*
  • Phosphorylation
  • Protein Binding
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • NF-kappa B
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • CREB-Binding Protein
  • CREBBP protein, human
  • CHUK protein, human
  • I-kappa B Kinase