A two-way street: LSD1 regulates chromatin boundary formation in S. pombe and Drosophila

Mol Cell. 2007 Apr 27;26(2):160-2. doi: 10.1016/j.molcel.2007.04.009.

Abstract

Two recent studies in Molecular Cell (Lan et al., 2007; Rudolph et al., 2007) implicate histone demethylation by LSD1 in the regulation of boundaries between silenced and active chromatin domains in both fission yeast and flies, but by distinct mechanisms.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Chromatin / enzymology*
  • Chromatin / genetics*
  • Drosophila Proteins / genetics*
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / enzymology*
  • Drosophila melanogaster / genetics*
  • Euchromatin / enzymology
  • Euchromatin / genetics
  • Genes, Fungal
  • Genes, Insect
  • Heterochromatin / enzymology
  • Heterochromatin / genetics
  • Histones / metabolism
  • Models, Biological
  • Oxidoreductases, N-Demethylating / genetics*
  • Oxidoreductases, N-Demethylating / metabolism*
  • Schizosaccharomyces / enzymology*
  • Schizosaccharomyces / genetics*
  • Schizosaccharomyces pombe Proteins / genetics
  • Schizosaccharomyces pombe Proteins / metabolism

Substances

  • Chromatin
  • Drosophila Proteins
  • Euchromatin
  • Heterochromatin
  • Histones
  • Schizosaccharomyces pombe Proteins
  • Oxidoreductases, N-Demethylating