Active genes at the nuclear pore complex

Curr Opin Cell Biol. 2007 Jun;19(3):305-10. doi: 10.1016/ Epub 2007 Apr 27.


The nucleus is spatially and functionally organized and its architecture is now seen as a key contributor to genome functions. A central component of this architecture is the nuclear envelope, which is studded with nuclear pore complexes that serve as gateways for communication between the nucleoplasm and cytoplasm. Although the nuclear periphery has traditionally been described as a repressive compartment and repository for gene-poor chromosome regions, several recent studies in yeast have demonstrated that repressive and activating domains can both be positioned at the periphery of the nucleus. Moreover, association with the nuclear envelope favors the expression of particular genes, demonstrating that nuclear organization can play an active role in gene regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Genes, Fungal*
  • Humans
  • Models, Biological
  • Nuclear Envelope / chemistry
  • Nuclear Envelope / metabolism*
  • Nuclear Pore / chemistry
  • Nuclear Pore / genetics
  • Nuclear Pore / metabolism*
  • Saccharomyces cerevisiae / cytology*
  • Saccharomyces cerevisiae / genetics*