Relationships between circulating hormone levels, mammographic percent density and breast cancer risk factors in postmenopausal women

Breast Cancer Res Treat. 2008 Mar;108(1):57-67. doi: 10.1007/s10549-007-9577-9. Epub 2007 Apr 28.


Background: Endogenous hormones and insulin-like growth factors (IGF) play a central role in breast cancer development. Mammographic density, an important breast cancer risk factor, has been associated with these biomarkers in premenopausal women. The aim of this study was to assess the relationships between circulating hormones, clinical features related to breast cancer risk and mammographic density in postmenopausal women.

Subjects and methods: The study included 226 postmenopausal women participating in a clinical prevention trial. We performed baseline measurements of mammographic percent density and circulating levels of estradiol, sex-hormone binding globulin (SHBG), follicle stimulating hormone (FSH), prolactin, C-terminal cross-link telopeptide, IGF-I, and IGF binding protein-3.

Results: Median age and time since last menses were 52 years and 15 months, respectively. Median body mass index was 24.1 kg/m(2). After adjusting for age and body mass index, estradiol was the only biomarker significantly correlated with mammographic density (r = 0.17; P = 0.04). Women with normal body mass index had higher mammographic density (P < 0.001), higher SHBG (P < 0.0001), higher FSH (P = 0.002) and lower estradiol levels (P = 0.01) than those who were overweight. Women who had previous biopsies for benign breast disease had a higher mammographic density (P = 0.006).

Conclusions: In these recently postmenopausal women, mammographic percent density is directly associated with circulating estradiol levels. Our results provide further support to the role of circulating hormones in breast cancer risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Mass Index
  • Breast Neoplasms / blood*
  • Breast Neoplasms / pathology*
  • Enzyme-Linked Immunosorbent Assay
  • Estradiol / blood
  • Female
  • Follicle Stimulating Hormone / blood
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3 / blood
  • Insulin-Like Growth Factor I / analysis
  • Mammography*
  • Middle Aged
  • Postmenopause / blood*
  • Prolactin / blood
  • Risk Factors
  • Sex Hormone-Binding Globulin / analysis


  • Insulin-Like Growth Factor Binding Protein 3
  • Sex Hormone-Binding Globulin
  • Estradiol
  • Insulin-Like Growth Factor I
  • Prolactin
  • Follicle Stimulating Hormone