Comparison between creatinine and cystatin C-based GFR equations in renal transplantation

Nephrol Dial Transplant. 2007 Sep;22(9):2659-68. doi: 10.1093/ndt/gfm243. Epub 2007 Apr 30.

Abstract

Background: Estimation of glomerular filtration rate (GFR) from serum creatinine (Scr) or cystatin C (Cys C) exhibit variable performances.

Methods: We compared the performances of 14 Scr and 9 Cys C estimated GFR equations using inulin clearance (Clin) as the reference test in 103 stable renal transplant populations. Bias, precision, receiving operation characteristics (ROC), accuracy within 30% ranges from the reference method and agreements of each test were compared.

Results: Mean Clin was 46.4+/-20.9 ml/min/1.73 m2. Scr and Cys C levels correlated well with each other (r=0.83, P<0.0001) and with Clin (r=-0.57 and -0.53, P<0.001, respectively). ROC analysis demonstrated no superiority of Cys C over Scr. Gats equation achieved the highest accuracy of 70% in patients with GFR>or=60 ml/min/1.73 m2. In patients with GFR>or=60 ml/min/1.73 m2, the Nankivell equation demonstrated the highest accuracy of 73.91%. Cys C-based equations were not depicted to be thoroughly accurate. Bias, precision and agreement were otherwise similar in all GFR tests.

Conclusion: Scr-based equations did not appear to be inferior to Cys C-based equations as a means to estimate GFR in renal transplant patients.

Publication types

  • Comparative Study

MeSH terms

  • Aged, 80 and over
  • Creatinine / blood*
  • Cystatin C
  • Cystatins / blood*
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Inulin / metabolism
  • Kidney Transplantation*
  • Male
  • Models, Biological
  • ROC Curve

Substances

  • CST3 protein, human
  • Cystatin C
  • Cystatins
  • Inulin
  • Creatinine