Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model

Matthew E Griffith; James E Moon; Erica N Johnson; Kyra P Clark; Joshua S Hawley; Duane R Hospenthal; Clinton K Murray

doi:10.1128/AAC.00240-07

Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model

Antimicrob Agents Chemother. 2007 Jul;51(7):2615-7. doi: 10.1128/AAC.00240-07. Epub 2007 Apr 30.

Authors

Matthew E Griffith¹, James E Moon, Erica N Johnson, Kyra P Clark, Joshua S Hawley, Duane R Hospenthal, Clinton K Murray

Affiliation

¹ Infectious Disease Service, MCHE-MDI, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA. matthew.griffith@amedd.army.mil

Abstract

Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

Publication types

Comparative Study

MeSH terms

Acute Disease
Animals
Anti-Bacterial Agents / pharmacology*
Ciprofloxacin / pharmacology
Cricetinae
Disease Models, Animal
Dose-Response Relationship, Drug
Doxycycline / pharmacology
Female
Fluoroquinolones / pharmacology*
Gatifloxacin
Injections, Intraperitoneal
Leptospira interrogans / classification
Leptospira interrogans / drug effects*
Leptospirosis / drug therapy*
Leptospirosis / mortality
Levofloxacin
Mesocricetus
Ofloxacin / pharmacology
Serotyping
Survival Analysis

Substances

Anti-Bacterial Agents
Fluoroquinolones
Ciprofloxacin
Levofloxacin
Ofloxacin
Gatifloxacin
Doxycycline