Aetiology of the relationship between callous-unemotional traits and conduct problems in childhood

Br J Psychiatry Suppl. 2007 May:49:s33-8. doi: 10.1192/bjp.190.5.s33.

Abstract

Background: A callous and unemotional disposition is an indicator of early-onset antisocial behaviour.

Aims: To investigate the extent to which genetic influences contribute to the overlap between callous-unemotional traits and conduct problems in a large population sample of 7-year-old twins.

Method: Teachers provided ratings of callous-unemotional traits and conduct problems for 3434 twin pairs from the Twins Early Development Study. Model-fitting analyses were performed across the continuum of scores and at the extremes.

Results: The phenotypic relationship was primarily genetically mediated, both across the continuum and at the extremes and was substantial.

Conclusions: At 7 years of age, genetic influences on callous-unemotional traits overlap substantially with genetic influences on conduct problems. This combination should guide selection criteria in future molecular genetic studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Affective Symptoms / genetics*
  • Child
  • Conduct Disorder / genetics*
  • Conduct Disorder / psychology
  • Diseases in Twins / genetics*
  • Diseases in Twins / psychology
  • Female
  • Humans
  • Male
  • Sex Factors
  • Twins, Dizygotic
  • Twins, Monozygotic