Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: a prospective longitudinal cohort study

Arthritis Rheum. 2007 May 15;57(4):626-32. doi: 10.1002/art.22680.


Objective: The contribution of genetics to osteoarthritis (OA) progression is not known. To gain more insight into whether familial factors play a role in disease progression of OA, we analyzed familial aggregation of radiologic OA progression in a study of sibling pairs (the Genetics, Arthrosis, and Progression [GARP] study).

Methods: A total of 105 white probands and their 105 siblings with OA at multiple joint sites were included in a prospective cohort study. Radiologic progression of OA was defined as a 1-point score increase in total scores for severity of joint space narrowing (JSN) or osteophytes on standardized radiographs of the hands, knees, and hips obtained at baseline and after 2 years. Odds ratios were calculated for siblings and probands sharing radiologic disease progression.

Results: A total of 100 probands and 93 siblings were followed for 2 years (median age 60 years, 80% women). In 92 sibling pairs both the proband and sibling had complete radiographic followup. Radiologic progression of JSN and osteophytes was present in 47% and 42% of the probands and 34% and 37% of the siblings, respectively. The odds ratios (95% confidence intervals), adjusted for age, sex, and body mass index, of a sibling having radiologic progression if the proband had progression were 3.0 (1.2-7.8) for JSN progression and 1.5 (0.6-3.6) for osteophyte progression. A dose-response relationship was found between the amount of increase in JSN total scores among probands and the progression of JSN in siblings.

Conclusion: Familial factors played a role in the radiologic progression of JSN over 2 years in patients with OA at multiple sites.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Arthrography*
  • Disease Progression
  • Family Health*
  • Female
  • Follow-Up Studies
  • Hand Joints / diagnostic imaging
  • Hip Joint / diagnostic imaging
  • Humans
  • Knee Joint / diagnostic imaging
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Osteoarthritis, Hip* / diagnostic imaging
  • Osteoarthritis, Hip* / epidemiology
  • Osteoarthritis, Hip* / genetics
  • Osteoarthritis, Knee* / diagnostic imaging
  • Osteoarthritis, Knee* / epidemiology
  • Osteoarthritis, Knee* / genetics
  • Risk Factors
  • Severity of Illness Index
  • Siblings