Effectiveness of kamishoyosan for premenstrual dysphoric disorder: open-labeled pilot study

Psychiatry Clin Neurosci. 2007 Jun;61(3):323-5. doi: 10.1111/j.1440-1819.2007.01649.x.


The purpose of the present paper was to investigate the efficacy of kamishoyosan (TJ-24), a traditional Japanese herbal formula (kampo), for outpatients with premenstrual dysphoric disorder (PMDD) as an alternative treatment. Thirty patients with PMDD were treated with TJ-24 for six menstrual cycles. Nineteen patients (63.3%) had >50% improvement in the total score of the Hamilton Depression Rating Scale (HAM-D) Scale (17 items) in the late luteal phase. Fourteen patients (46.7%) went into remission (total HAM-D score <7). In the present study many patients with PMDD were successfully treated with TJ-24.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Depression / drug therapy
  • Depression / etiology
  • Depression / psychology
  • Drugs, Chinese Herbal / adverse effects*
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Hot Flashes / drug therapy
  • Humans
  • Middle Aged
  • Pilot Projects
  • Premenstrual Syndrome / drug therapy*
  • Premenstrual Syndrome / psychology
  • Psychiatric Status Rating Scales


  • Drugs, Chinese Herbal
  • kamisyoyo san