Azelaic acid (15% gel) in the treatment of acne rosacea

Int J Dermatol. 2007 May;46(5):533-8. doi: 10.1111/j.1365-4632.2005.02769.x.


In December of 2002, the FDA approved azelaic acid 15% gel for the topical treatment of inflammatory papules and pustules of mild to moderate rosacea. Azelaic acid is a saturated dicarboxylic acid, which is naturally occurring and has been used in the treatment of rosacea, acne, and melasma. The 15% gel has a high efficacy and is generally well tolerated, with the local irritation (burning, stinging, itching, and scaling) being typically mild and transient. Azelaic acid 15% gel is considered effective and safe as a therapy for inflammatory papulo-pustular rosacea and is suitable for use on all skin types.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Dermatologic Agents / adverse effects
  • Dermatologic Agents / therapeutic use*
  • Dicarboxylic Acids / adverse effects
  • Dicarboxylic Acids / therapeutic use*
  • Gels
  • Humans
  • Ointments
  • Randomized Controlled Trials as Topic
  • Rosacea / drug therapy*
  • Treatment Outcome


  • Dermatologic Agents
  • Dicarboxylic Acids
  • Gels
  • Ointments
  • azelaic acid