Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function

Protein Sci. 2007 Jun;16(6):1042-52. doi: 10.1110/ps.072791207. Epub 2007 May 1.


The murine molecule dectin-1 (known as the beta-glucan receptor in humans) is an immune cell surface receptor implicated in the immunological defense against fungal pathogens. Sequence analysis has indicated that the dectin-1 extracellular domain is a C-type lectin-like domain, and functional studies have established that it binds fungal beta-glucans. We report several dectin-1 crystal structures, including a high-resolution structure and a 2.8 angstroms resolution structure in which a short soaked natural beta-glucan is trapped in the crystal lattice. In vitro characterization of dectin-1 in the presence of its natural ligand indicates higher-order complex formation between dectin-1 and beta-glucans. These combined structural and biophysical data considerably extend the current knowledge of dectin-1 structure and function, and suggest potential mechanisms of defense against fungal pathogens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cations, Divalent
  • Crystallography, X-Ray
  • Fungal Proteins / chemistry*
  • Fungal Proteins / metabolism
  • Glucans
  • Lectins, C-Type
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism
  • Mice
  • Models, Molecular
  • Nerve Tissue Proteins / chemistry*
  • Nerve Tissue Proteins / metabolism
  • Polysaccharides / chemistry
  • Polysaccharides / metabolism
  • Protein Binding
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Receptors, Immunologic / chemistry*
  • Receptors, Immunologic / metabolism
  • Structure-Activity Relationship
  • beta-Glucans / chemistry
  • beta-Glucans / metabolism


  • Cations, Divalent
  • Fungal Proteins
  • Glucans
  • Lectins, C-Type
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Polysaccharides
  • Receptors, Immunologic
  • beta-Glucans
  • beta-glucan receptor
  • dectin 1
  • laminaran

Associated data

  • PDB/2BPD
  • PDB/2BPE
  • PDB/2BPH
  • PDB/2CL8