Treatment of feline hypertension with transdermal amlodipine: a pilot study

J Am Anim Hosp Assoc. May-Jun 2007;43(3):149-56. doi: 10.5326/0430149.

Abstract

This prospective study evaluated transdermal amlodipine for the control of hypertension in six cats. Cats were treated with oral amlodipine until blood pressures decreased to <180 mm Hg. They were maintained on this dose for 7 days and then administered identical doses of transdermal amlodipine for 7 days. Oral amlodipine decreased pressure by a median of 73 mm Hg, which subsequently increased by 20 mm Hg after 7 days of transdermal amlodipine. Plasma concentrations of amlodipine were measured after oral and transdermal dosing. Additional studies are needed to determine dosing, pharmacokinetics, and efficacy.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Amlodipine / administration & dosage*
  • Amlodipine / blood
  • Amlodipine / pharmacokinetics
  • Animals
  • Antihypertensive Agents / administration & dosage*
  • Antihypertensive Agents / blood
  • Antihypertensive Agents / pharmacokinetics
  • Biological Availability
  • Blood Pressure / drug effects
  • Cat Diseases / drug therapy*
  • Cats
  • Female
  • Hypertension / drug therapy
  • Hypertension / veterinary*
  • Male
  • Models, Biological
  • Pilot Projects
  • Prospective Studies

Substances

  • Antihypertensive Agents
  • Amlodipine