RNA-binding proteins: modular design for efficient function

Nat Rev Mol Cell Biol. 2007 Jun;8(6):479-90. doi: 10.1038/nrm2178.


Many RNA-binding proteins have modular structures and are composed of multiple repeats of just a few basic domains that are arranged in various ways to satisfy their diverse functional requirements. Recent studies have investigated how different modules cooperate in regulating the RNA-binding specificity and the biological activity of these proteins. They have also investigated how multiple modules cooperate with enzymatic domains to regulate the catalytic activity of enzymes that act on RNA. These studies have shown how, for many RNA-binding proteins, multiple modules define the fundamental structural unit that is responsible for biological function.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Catalytic Domain
  • Dimerization
  • Enzyme Activation
  • Humans
  • Models, Molecular
  • Nucleic Acid Conformation
  • Protein Conformation*
  • RNA / chemistry
  • RNA / metabolism*
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism*


  • RNA-Binding Proteins
  • RNA