Reduced threshold for cortical spreading depression in female mice

Ann Neurol. 2007 Jun;61(6):603-6. doi: 10.1002/ana.21138.


The prevalence of migraine is much greater in female than male individuals. Cortical spreading depression (CSD) is thought to be a fundamental mechanism of migraine, and CSD in rodents is used as a model for migraine. We used optical intrinsic signal imaging and electrophysiological techniques to investigate CSD in C57Bl/6 mice. Using two different methods for induction of CSD, we found that female mice had a significantly reduced threshold for induction of CSD compared with male mice. These results suggest an increased cortical excitability in female mice that may be independent of the estrous cycle.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cortical Spreading Depression* / drug effects
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Electrophysiology
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Migraine Disorders / physiopathology*
  • Potassium Chloride / pharmacology
  • Sex Factors


  • Potassium Chloride