Chaperonopathies and chaperonotherapy

FEBS Lett. 2007 Jul 31;581(19):3681-8. doi: 10.1016/j.febslet.2007.04.030. Epub 2007 Apr 24.


The study of molecular chaperones (genetics, structure, location, physiology, pathology, and therapeutics) has developed into a science with specific objectives, methods, and hypotheses, a discipline we called chaperonology. Subdisciplines of chaperonology include the study of pathological chaperones (chaperonopathies) and the analysis of their genes in sequenced genomes (chaperonomics). Chaperonopathies are pathological conditions in which one type of chaperone is deficient due to a genetic or acquired defect that modifies the chaperone's structure and/or makes the chaperone unavailable for functioning when needed. Experimental and clinical data show that chaperones and their genes can be used for treating various pathological conditions, thus justifying the development of chaperonotherapy. We discuss recent work showing that chaperonotherapy is on solid foundations: the data demonstrate that molecular chaperones counteract pathogenetic mechanisms in disease and during stress.

Publication types

  • Review

MeSH terms

  • Brain Diseases / drug therapy*
  • Brain Diseases / metabolism*
  • Brain Diseases / prevention & control
  • Cytoprotection*
  • Gene Expression / drug effects
  • Genetic Therapy
  • Humans
  • Molecular Chaperones / genetics
  • Molecular Chaperones / metabolism*
  • Molecular Chaperones / therapeutic use*
  • Promoter Regions, Genetic
  • Protein Folding


  • Molecular Chaperones