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Comparative Study
. 2007 May 15;178(10):6051-7.
doi: 10.4049/jimmunol.178.10.6051.

The Insulin-Specific T Cells of Nonobese Diabetic Mice Recognize a Weak MHC-binding Segment in More Than One Form

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Comparative Study

The Insulin-Specific T Cells of Nonobese Diabetic Mice Recognize a Weak MHC-binding Segment in More Than One Form

Matteo G Levisetti et al. J Immunol. .
Free article

Abstract

Several naturally occurring anti-insulin CD4 T cells were isolated from islet infiltrates of NOD mice. In accordance with the results of others, these T cells recognized the segment of the beta-chain from residues 9-23. Peptides encompassing the B:(9-23) sequence bound weakly to I-Ag7 in two main contiguous registers in which two residues at the carboxyl end, P20Gly and P21Glu, influenced binding and T cell reactivity. Naturally occurring insulin-reactive T cells exhibited differing reactivities with the carboxyl-terminal amino acids, although various single residue changes in either the flanks or the core segments affected T cell responses. The insulin peptides represent another example of a weak MHC-binding ligand that is highly immunogenic, giving rise to distinct populations of autoimmune T cells.

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