Antidepressant-like Effects of Albizzia Julibrissin in Mice: Involvement of the 5-HT1A Receptor System

Pharmacol Biochem Behav. 2007 May;87(1):41-7. doi: 10.1016/j.pbb.2007.03.018. Epub 2007 Apr 6.

Abstract

The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h before the tail suspension test. Acute treatment with MCAJ at 200 mg/kg significantly reduced the immobility time compared with the control group, and thus showed an antidepressant-like effect. This effect was comparable to that of imipramine at 10 mg/kg. This antidepressant-like effect was reversed by treatment with WAY-100635 (a 5-HT1A receptor antagonist) or pindolol (a 5-HT1A/1B receptor antagonist). However, the antidepressant effect of MCAJ was not effected by treatment with GR55562 (a 5-HT1B receptor antagonist) or ketanserin (a 5-HT2A receptor antagonist). Therefore, our findings suggest that MCAJ exerts its antidepressant-like effect via the 5-HT1A receptor system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology
  • Albizzia / chemistry*
  • Animals
  • Antidepressive Agents / pharmacology*
  • Benzamides / pharmacology
  • Body Temperature / drug effects
  • Hindlimb Suspension
  • Ketanserin / pharmacology
  • Male
  • Methylene Chloride
  • Mice
  • Mice, Inbred ICR
  • Motor Activity / drug effects
  • Pindolol / pharmacology
  • Piperazines / pharmacology
  • Plant Extracts / pharmacology
  • Pyridines / pharmacology
  • Receptor, Serotonin, 5-HT1A / drug effects*
  • Serotonin Antagonists / pharmacology
  • Solvents

Substances

  • Adrenergic beta-Antagonists
  • Antidepressive Agents
  • Benzamides
  • Piperazines
  • Plant Extracts
  • Pyridines
  • Serotonin Antagonists
  • Solvents
  • Receptor, Serotonin, 5-HT1A
  • 3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamide
  • Methylene Chloride
  • N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
  • Ketanserin
  • Pindolol