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. 2007 May;87(1):41-7.
doi: 10.1016/j.pbb.2007.03.018. Epub 2007 Apr 6.

Antidepressant-like Effects of Albizzia Julibrissin in Mice: Involvement of the 5-HT1A Receptor System

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Antidepressant-like Effects of Albizzia Julibrissin in Mice: Involvement of the 5-HT1A Receptor System

Ji-Hyun Kim et al. Pharmacol Biochem Behav. .

Abstract

The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h before the tail suspension test. Acute treatment with MCAJ at 200 mg/kg significantly reduced the immobility time compared with the control group, and thus showed an antidepressant-like effect. This effect was comparable to that of imipramine at 10 mg/kg. This antidepressant-like effect was reversed by treatment with WAY-100635 (a 5-HT1A receptor antagonist) or pindolol (a 5-HT1A/1B receptor antagonist). However, the antidepressant effect of MCAJ was not effected by treatment with GR55562 (a 5-HT1B receptor antagonist) or ketanserin (a 5-HT2A receptor antagonist). Therefore, our findings suggest that MCAJ exerts its antidepressant-like effect via the 5-HT1A receptor system.

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