Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: autoantibodies to Abeta((25-35)) oligomers, S100b and neurotransmitters

J Neuroimmunol. 2007 May;186(1-2):181-92. doi: 10.1016/j.jneuroim.2007.03.023. Epub 2007 May 2.

Abstract

Alzheimer's disease (AD) autoimmunity is a focus for dementia prevention. Generated autoantibodies against major etiopathogenic molecular targets as neuroimmune markers of dementia were measured by ELISA in patient sera. Biphasic antibody levels to Abeta((25-35)) oligomers, S100b and DA were detected during distinctly diagnosed dementia stages. Abeta((25-35)) oligomer autoimmune responses reflected mild to moderate AD dementia, while those to S100b, DA and the S100b concentrations, matched moderate to severe dementia progression. 5-HT antibodies increased during mild dementia and plateaued thereafter. This autoimmunity pattern may be used as a differential biomarker profile in designing AD therapeutic strategies involving early vaccination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / complications
  • Alzheimer Disease / immunology*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Amyloid beta-Peptides / immunology*
  • Antibodies / metabolism*
  • Cognition Disorders / etiology
  • Dopamine
  • Enzyme-Linked Immunosorbent Assay / methods
  • Female
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging / methods
  • Nerve Degeneration / immunology*
  • Nerve Degeneration / metabolism
  • Nerve Degeneration / pathology
  • Nerve Growth Factors / immunology*
  • Peptide Fragments / immunology
  • Peptide Fragments / metabolism
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins / immunology*
  • Serotonin / metabolism

Substances

  • Amyloid beta-Peptides
  • Antibodies
  • Nerve Growth Factors
  • Peptide Fragments
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins
  • S100B protein, human
  • Serotonin
  • Dopamine