TRP channel knockout mice lose their cool

Neuron. 2007 May 3;54(3):345-7. doi: 10.1016/j.neuron.2007.04.025.


Heat and cold transduction by peripheral sensory neurons is a fundamental step in the avoidance of dangerous thermal extremes. In this issue of Neuron, Dhaka et al. and Colburn et al. report that mice lacking the cold- and menthol-gated ion channel TRPM8 exhibit deficient behavioral responses to cold temperatures.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cold Temperature*
  • Mice
  • Mice, Knockout / physiology*
  • TRPM Cation Channels / deficiency*
  • Thermosensing / genetics*


  • TRPM Cation Channels
  • TRPM8 protein, mouse