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Randomized Controlled Trial
, 174 (2-3), 173-7

Excretion of Delta9-tetrahydrocannabinol in Sweat

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Randomized Controlled Trial

Excretion of Delta9-tetrahydrocannabinol in Sweat

Marilyn A Huestis et al. Forensic Sci Int.

Abstract

Sweat testing is a noninvasive technique for monitoring drug exposure over a 7-day period in treatment, criminal justice, and employment settings. We evaluated Delta(9)-tetrahydrocannabinol (THC) excretion in 11 daily cannabis users after cessation of drug use. PharmChek sweat patches worn for 7 days were analyzed for THC by gas chromatography-mass spectrometry (GC/MS). The limit of quantification (LOQ) for the method was 0.4 ng THC/patch. Sweat patches worn the first week of continuously monitored abstinence had THC above the United States Substance Abuse Mental Health Services Administration's proposed cutoff concentration for federal workplace testing of 1 ng THC/patch. Mean+/-S.E.M. THC concentrations were 3.85+/-0.86 ng THC/patch. Eight of 11 subjects had negative patches the second week and one produced THC positive patches for 4 weeks of monitored abstinence. We also tested daily and weekly sweat patches from seven subjects who were administered oral doses of up to 14.8 mg THC/day for five consecutive days. In this oral THC administration study, no daily or weekly patches had THC above the LOQ; concurrent plasma THC concentrations were all less than 6.1 microg/L. In conclusion, using proposed federal cutoff concentrations, most daily cannabis users will have a positive sweat patch in the first week after ceasing drug use and a negative patch after subsequent weeks, although patches may remain positive for 4 weeks or more. Oral ingestion of up to 14.8 mg THC daily does not produce a THC positive sweat patch test.

Figures

Figure 1
Figure 1
Δ9-tetrahydrocannabinol (THC) excreted in sweat. Dashed line indicates 1.0 ng/patch cutoff concentration proposed by the Substance Abuse Mental Health Services Administration. * indicates amount of THC less than the assay limit of quantification (0.4 ng/patch)

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