Telomerase and the aging process

Exp Gerontol. 2007 Jul;42(7):575-81. doi: 10.1016/j.exger.2007.03.007. Epub 2007 Mar 30.


The level of telomerase activity is important in determining telomere length in aging cells and tissues. Here evidence on the importance of telomerase activity is reviewed with respect to aging rates of mammalian species and the health and life span of individuals within a species. The significance of telomerase reactivation for both cancer development and for immortalizing cells for therapeutic processes is assessed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Cell Division / physiology
  • Health Status
  • Humans
  • Mammals
  • Telomerase / metabolism*


  • Telomerase