Endogenous synthesis of coenzyme Q in eukaryotes

Mitochondrion. 2007 Jun;7 Suppl(Suppl):S62-71. doi: 10.1016/j.mito.2007.03.007. Epub 2007 Mar 30.

Abstract

Coenzyme Q (Q) functions in the mitochondrial respiratory chain and serves as a lipophilic antioxidant. There is increasing interest in the use of Q as a nutritional supplement. Although, the physiological significance of Q is extensively investigated in eukaryotes, ranging from yeast to human, the eukaryotic Q biosynthesis pathway is best characterized in the budding yeast Saccharomyces cerevisiae. At least ten genes (COQ1-COQ10) have been shown to be required for Q biosynthesis and function in respiration. This review highlights recent knowledge about the endogenous synthesis of Q in eukaryotes, with emphasis on S. cerevisiae as a model system.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Caenorhabditis elegans / metabolism
  • Carbon / chemistry
  • Eukaryotic Cells / metabolism
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Lipids / chemistry
  • Mitochondria / metabolism
  • Models, Biological
  • Models, Chemical
  • Protein Transport
  • Saccharomyces cerevisiae / metabolism
  • Ubiquinone / biosynthesis*
  • Ubiquinone / chemistry*
  • Ubiquinone / metabolism

Substances

  • Antioxidants
  • Lipids
  • Ubiquinone
  • Carbon