Abstract
The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cd2+) at 3 microM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 microM of Cd(2+). These results suggest that Cd(2+) impacts the gene expression of IGFBP-1, which leads to production of IGFBP-1.
MeSH terms
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Cadmium / pharmacology*
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Carcinoma, Hepatocellular / metabolism*
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Carcinoma, Hepatocellular / pathology
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Cations / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Formazans / metabolism
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Humans
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Insulin-Like Growth Factor Binding Protein 1 / biosynthesis*
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Liver Neoplasms / metabolism*
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Liver Neoplasms / pathology
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RNA, Messenger / metabolism*
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Tetrazolium Salts / metabolism
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Time Factors
Substances
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Cations
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Formazans
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Insulin-Like Growth Factor Binding Protein 1
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RNA, Messenger
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Tetrazolium Salts
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Cadmium
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MTT formazan